Methanol → N2-(tert-butoxycarbonyl)-N6-(iminomethoxymethyl)-L-lysine tert-butyl ester hydrochloride
反応式
[C:1]([O:5][C:6](=[O:23])[C@H:7]([CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]#N)[NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])([CH3:4])([CH3:3])[CH3:2].C([O:28][C:29]([NH:31][C@H](C(O)=O)CCCCNC=NOCC)=O)(C)(C)C.CO.[Cl:48]CCl>>[ClH:48].[C:1]([O:5][C:6](=[O:23])[C@H:7]([CH2:16][CH2:17][CH2:18][CH2:19][NH:20][CH2:21][O:28][CH:29]=[NH:31])[NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])([CH3:4])([CH3:3])[CH3:2]参加物
5
実験手順
From 1.6 g (4.89 mmol) N2-(tert-butoxycarbonyl)-N6-(cyano)-L-lysine tert-butyl ester was prepared 1.5 g (75%) of foamy solid N2-(tert-butoxycarbonyl)-N6-(ethoxyiminomethyl)-L-lysine tart-butyl ester hydrochloride by the method described for N2-(tert-butoxycarbonyl)-N5-(imonomethoxymethyl)-L-ornithine tert-butyl ester hydrochloride. TLC (methanol:dichloromethane/1:9) Rf=0.36. Mass spectrum (CI) 360 (MH+, 60%).
出典と根拠
- ORDレコード
- ord-f5059cf59a654b4d81205b4e8bf7ef59
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06297276B1
反応ノート
読み込み中…