Phenyl isocyanate → HCID 178418533、化合物

HRID 3791

反応式

HRID 3791 の反応式
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:10].Cl.[CH2:12]([N:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH2:27][SH:28])[CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(CC)CC)C>C(Cl)Cl>[OH2:9].[ClH:10].[ClH:10].[C:1]1([NH:7][C:8](=[SH:28][CH2:27][CH2:26][CH2:25][N:22]2[CH2:21][CH2:20][N:19]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:24][CH2:23]2)[OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 7672Phenyl isocyanateHCID 8471TriethylamineHCID 137311143-(4-Benzylpiperazin-1-yl)propanethiol dihydrochloride

生成物 1

HCID 178418533HCID 178418533、化合物収率 41.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.6 g of phenyl isocyanate were added to a solution of 4.0 g of 3-(4-benzylpiperazin-1-yl)propanethiol dihydrochloride and 2.6 g of triethylamine in 50 ml of methylene chloride. The mixture was refluxed for four hours, washed with water and dried (sodium sulfate). Precipitation of the salt with ethereal hydrochloric acid gave 1.2 g (20% of theory) of N-phenyl-S-[3-(4-benzylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate as a white crystalline solid, M.p. 216°-219° C.

後処理

  1. temperatureThe mixture was refluxed for four hours
  2. washwashed with water
  3. dry with materialdried (sodium sulfate)
  4. customPrecipitation of the salt with ethereal hydrochloric acid

出典と根拠

ORDレコード
ord-e0666140f18d4bf7be07a753ad3f837c
出典データセット
uspto-grants-1988_02
特許番号
US04722926

関連ノート

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