化工社化工社 化学情報印刷レポート · 研究参考用
3-Aminoazetidine, 3-BOC protected → tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminoazetidine, 3-BOC protected | HCID 1519405 | — |
| 反応物 | 2-(6-Chloropyrimidin-4-yl)-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-one | HCID 86672328 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate | HCID 70302327 | — |
反応手順
200 mg (0.7 mmol) of the compound from Example 23 and 252 mg (1.5 mmol) of tert-butyl azetidin-3-ylcarbamate are suspended in 6 ml of ethanol and reacted at 120° C. in a single-mode microwave oven (CEM Explorer) for 40 min. The solid formed is filtered off, washed twice with in each case 0.5 ml of ethanol and dried under high vacuum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524699B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-61ffad6f04f34b6db1d26cca5588c567 |
| 出典メモ | uspto-grants-2013_09 |