1-Bromo-3-chloropropane → 4-Chlorobenzyl-4-(3-chloropropyl)piperazine dihydrochloride
反応式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[OH-].[K+].Br[CH2:18][CH2:19][CH2:20][Cl:21]>CS(C)=O>[ClH:1].[ClH:21].[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([CH2:18][CH2:19][CH2:20][Cl:21])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1参加物
5
実験手順
Utilizing the procedure described in Example 1(a), 20.0 g of 1-(4-chlorobenzyl)piperazine, 100 ml of dimethyl sulfoxide, 15.0 g of potassium hydroxide and 15.0 of 1-bromo-3-chloropropane yielded 25.1 g (74% of theory) of 1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.
出典と根拠
- ORDレコード
- ord-2696e8dc20db40a1b56b86bc942054c8
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04722926
反応ノート
読み込み中…