3-Fluorobenzoyl chloride → Ethyl 9-chloro-3-(3-fluorobenzoyl)-1,2,3,6-tetrahydroazepino[4,5-B]indole-5-carboxylate

HRID 37923

反応式

HRID 37923 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12][NH:13][CH2:14][CH2:15][C:5]=3[C:4]=2[CH:3]=1.[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](Cl)=[O:26]>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12][N:13]([C:25](=[O:26])[C:24]4[CH:28]=[CH:29][CH:30]=[C:22]([F:21])[CH:23]=4)[CH2:14][CH2:15][C:5]=3[C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 743763-Fluorobenzoyl chlorideHCID 66640154Ethyl 9-chloro-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

生成物 1

HCID 57559114Ethyl 9-chloro-3-(3-fluorobenzoyl)-1,2,3,6-tetrahydroazepino[4,5-B]indole-5-carboxylate

実験手順

The title compound was prepared in a manner similar to that described in Example 2A by using ethyl 9-chloro-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate and 3-fluorobenzoyl chloride; 1H-NMR (CDCl3): δ 10.61 (1H, br s), 8.07 (1H, s), 7.46 (2H, m), 7.28 (4H, m), 7.14 (1H, dd), 4.25 (2H, q), 4.19 (2H, t), 3.21 (2H, t), 1.22 (3H, t); MS (ES): 413 (MH+).

出典と根拠

ORDレコード
ord-435828ba86f04a34b0cec216d0eaefe0
出典データセット
uspto-grants-2013_09
特許番号
US08524704B2

関連ノート

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