Dichloromethane → HCID 54440811、化合物

HRID 379270ノート

反応式

HRID 379270 の反応式
O=[C:2]([CH3:11])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[O:10].[C:12](C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13].[CH2:37](Cl)Cl>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9](=[O:10])[CH3:37])[CH3:16]

参加物

4

反応物 3

HCID 6344Dichloromethane2 回HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 109316848-Oxo-nonanal

生成物 1

HCID 54440811HCID 54440811、化合物

実験手順

To a cooled (−40° C.) solution of 28-2 (10.8 g, 69.2 mmol) in 150 mL CH2Cl2 was added (carbethoxymethylene)triphenylphosphorane (24.1 g, 69.2 mmol) in 100 mL CH2Cl2 gradually over 15 min. The reaction mixture was stirred for 12 hr while it was warmed up to room temperature. After solvent removal, the residue was purified using silica gel flash chromatography (EtOAc/hexanes: 1:8 to 1:6) to afford the desired product 28-3 as an oil.

後処理

  1. customAfter solvent removal
  2. customthe residue was purified

出典と根拠

ORDレコード
ord-42dd264970e94fbf89d67c8092ec7d18
出典データセット
uspto-grants-2001_10
特許番号
US06297249B1

反応ノート

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