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Ethyl Acetoacetate → Ethyl 3-Hydroxybutyrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | Ethyl 3-Hydroxybutyrate | HCID 62572 | — |
反応手順
The same procedure of Example 5 is repeated with the only differences that 1.95 g of ethyl 3-oxo-butyrate were weighed and dissolved in MeOH/H2O 19/1 (v/v) and the cataIyst of Example I5 was utilized. At the end of the reaction, the ethyl 3-hydroxybutyrate resulted to be equal to 91%, while the ethyl 3-dimetoxybutyrate resulted equal to 9%. The stereoinduction was >99% in favour of the antipode (S).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06297387B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-9bef16eacdcc4df3840ab322f0c684be |
| 出典メモ | uspto-grants-2001_10 |