Water → N-Tert-butyl-6-morpholin-4-YL-4-O-tolyl-nicotinamide

HRID 379425ノート

反応式

HRID 379425 の反応式
[C:1]([NH:5][C:6](=[O:21])[C:7]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[CH:11][C:10](Cl)=[N:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.C(OCC)(=O)C.O>[Cl-].[Na+].O>[C:1]([NH:5][C:6](=[O:21])[C:7]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[CH:11][C:10]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 8083MorpholineHCID 8857Ethyl AcetateHCID 12167313N-(tert-butyl)-6-chloro-4-(o-tolyl)nicotinamide

生成物 1

HCID 12167315N-Tert-butyl-6-morpholin-4-YL-4-O-tolyl-nicotinamide収率 93.8%

試薬・触媒・溶媒 1

HCID 57417360Sodium chloride; water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 6.0 g (19 mMol) of N-tert.-butyl-6-chloro-4-o-tolyl-nicotinamide and 12 ml (138 mMol) morpholine was heated at 100° C. for 4 hours. After cooling to room temperature, extractive work-up with ethyl acetate, water and brine yielded 6.3 g (91%) of N-tert.-butyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide as a brown crystalline foam.

後処理

  1. temperatureAfter cooling to room temperature

出典と根拠

ORDレコード
ord-78c5e801341f4eaab40c10e5c6918b25
出典データセット
uspto-grants-2001_10
特許番号
US06297375B1

反応ノート

読み込み中…