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HRID 379474作成日：2026年10月26日

Ammonium formate → N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

https://huagongshe.com/reaction/379474

反応式

関与物質

役割名称HCID仕込み量
反応物Ammonium formateHCID 2723923—
反応物N-methyl-N-(4-(4-(1-(1-benzylimidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamideHCID 21697470—
触媒PalladiumHCID 23938—
溶媒MethanolHCID 887—
生成物N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamideHCID 21697366—

反応手順

Combine N-methyl-N-(4-(4-(1-(1-benzylimidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide (5 mmol) and 10% palladium-on-carbon (1.5 g) in methanol (50 mL). Add anhydrous ammonium formate (25 mmol). Heat to reflux. After 18 hours, filter, rinse with dichloromethane, and evaporate the filtrate in vacuo to give the title compound.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06297259B1
出典データセットuspto-grants-2001_10
ORD IDord-7caf438962724a72873b633243986422
出典メモuspto-grants-2001_10