関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | (+)-Methyl lactate | HCID 637514 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (R)-2-Hydroxy-1-morpholinopropan-1-one | HCID 14978393 | 87% |
反応手順
A mixture of methyl (R)-lactate (175 g) and morpholine (440 ml, 3 eq) was heated at 85° C. for 40 h. The mixture was evaporated under reduced pressure. Purification of the residue by silica gel chromatography (using n-hexane:ethyl acetate=1:1 ˜ethyl acetate as an eluent) gave 4-[(R)-2-hydroxypropionyl]morpholine (232.4 g, 87% yield) as a pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06300353B1 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-94c4aacdfda3451caec808415054f4a0 |
|---|
| 出典メモ | uspto-grants-2001_10 |
|---|
