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Diethyl[2-(4-nitrophenoxy)ethyl]amine → 4-(2-(Diethylamino)ethoxy)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl[2-(4-nitrophenoxy)ethyl]amine | HCID 88294 | — |
| 触媒 | HCID 178418390 | HCID 178418390 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(2-(Diethylamino)ethoxy)aniline | HCID 418932 | 98.4% |
反応手順
N,N-diethyl-2-(4-nitrophenoxy)ethylamine (28.19 g) was dissolved into methanol (300 ml) and subjected to hydration reaction at ambient pressure by adding 10% palladium carbon catalyst (1.5 g). After completion of hydration reaction, catalyst was removed by filtration. Filtrate was concentrated under vacuum to obtain N,N-diethyl-2-(4-aminophenoxy)ethylamine (24.25 g) as color-less oily substance.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06300368B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-72a8bec4006c486aac01b693cc55603e |
| 出典メモ | uspto-grants-2001_10 |