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2-Bromo-1-(3-methylphenyl)ethan-1-one → 3-Amino-6-chloro-2-(3-methylbenzoyl)-1-(ethoxycarbonyl)indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-1-(3-methylphenyl)ethan-1-one | HCID 10036129 | — |
| 反応物 | 4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile | HCID 18367888 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-Amino-6-chloro-2-(3-methylbenzoyl)-1-(ethoxycarbonyl)indole | HCID 18368043 | — |
反応手順
The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromo-3′-methylacetophenone (R. Yveline, G. Gerard, and M. Geroges, Chem.Pharm.Bull., 1992, 40, 1170.). tlc: Rf=0.5 (25% ethyl acetate in hexanes)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06300363B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-c7cdabc5ada74c36a5184db7236b94a1 |
| 出典メモ | uspto-grants-2001_10 |