関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Indole-3-acetonitrile | HCID 351795 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-benzyl-1H-indol-3-ylacetonitrile | HCID 11032169 | — |
反応手順
A mixture of 3-indolylacetonitrile (5 g, 32 mmol), triton B (40% in MeOH, 0.5 g), benzyl bromide (7. 8 mL, 2 eq.) and aqueous NaOH (50%, 12.6 mL) was stirred for 2 hours at 20° C. Water was added. Solid was collected by filtration and washed with water and hexane and dried under high vacuum to give [1-benzyl-1H-indol-3-yl]acetonitrile (6.97 g). MS (ES): 247 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524704B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-08afda3e79734efdb85638397638806e |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
