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HRID 380002作成日：2026年10月25日
Sodium Carbonate → (1S,2R)-3-Chloro-4'-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)biphenyl-4-carbonitrile
https://huagongshe.com/reaction/380002
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 4-Bromo-2-chlorobenzonitrile | HCID 7010420 | — |
| 反応物 | (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid | HCID 54413593 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (1S,2R)-3-Chloro-4'-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)biphenyl-4-carbonitrile | HCID 57191772 | 69% |
反応手順
Prepared according to the method described in Example 12b) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.20 g, Example 33), 4-bromo-2-chlorobenzonitrile (0.288 g), 2M aqueous sodium carbonate (0.76 ml) and tetrakis(triphenylphosphine)palladium (0) (0.075 g) in ethanol (5 ml) with heating at 90° C. for 4 hours. After work up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-10% ethanol in dichloromethane to give the title compound as an oil (0.18 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06300352B1 |
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| 出典データセット | uspto-grants-2001_10 |
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| ORD ID | ord-1e795bac0e8943e7ad5ad9d9ee0d679e |
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| 出典メモ | uspto-grants-2001_10 |
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