Methanol → Benzene, 1-bromo-3-(methylsulfonyl)-

HRID 380007

反応式

HRID 380007 の反応式
[Br:1][C:2]1[CH:3]=[C:4](SC)[CH:5]=[CH:6][CH:7]=1.O[O:11][S:12]([O-:14])=O.[K+].[CH3:16]O>O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([S:12]([CH3:16])(=[O:14])=[O:11])[CH:7]=1

参加物

5

反応物 3

HCID 887MethanolHCID 27356273-BromothioanisoleHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 2757146Benzene, 1-bromo-3-(methylsulfonyl)-

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

3-Bromothioanisole was dissolved in methanol (20 ml) and cooled to 0° C. (ice/water bath). A solution of Oxone® (9.22 g) in water (30 ml) was added to this and the resultant cloudy slurry was stirred at room temperature for 3 hours. The reaction mixture was diluted with water and product extracted with dichloromethane. The combined fractions of dichloromethane were washed with brine and dried over anhydrous magnesium sulfate. After filtration, solvent was removed by evaporation under reduced pressure to give the sub-title compound as a solid (1.02 g).

後処理

  1. extractionextracted with dichloromethane
  2. washThe combined fractions of dichloromethane were washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationAfter filtration, solvent
  5. customwas removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-3090aeaf62e34a87881bfec50af3c287
出典データセット
uspto-grants-2001_10
特許番号
US06300352B1

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