Methanol → Benzene, 1-bromo-3-(methylsulfonyl)-
反応式
[Br:1][C:2]1[CH:3]=[C:4](SC)[CH:5]=[CH:6][CH:7]=1.O[O:11][S:12]([O-:14])=O.[K+].[CH3:16]O>O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([S:12]([CH3:16])(=[O:14])=[O:11])[CH:7]=1参加物
5
実験手順
3-Bromothioanisole was dissolved in methanol (20 ml) and cooled to 0° C. (ice/water bath). A solution of Oxone® (9.22 g) in water (30 ml) was added to this and the resultant cloudy slurry was stirred at room temperature for 3 hours. The reaction mixture was diluted with water and product extracted with dichloromethane. The combined fractions of dichloromethane were washed with brine and dried over anhydrous magnesium sulfate. After filtration, solvent was removed by evaporation under reduced pressure to give the sub-title compound as a solid (1.02 g).
後処理
- extractionextracted with dichloromethane
- washThe combined fractions of dichloromethane were washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationAfter filtration, solvent
- customwas removed by evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-3090aeaf62e34a87881bfec50af3c287
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06300352B1
反応ノート
読み込み中…