Acetic Acid → 4-Bromo-2-methylbenzene-1-sulfonamide

HRID 380043ノート

反応式

HRID 380043 の反応式
[Br:1][C:2]1[CH:3]=C([CH:6]=[CH:7][C:8]=1C)N.N([O-])=O.[Na+].Cl.[Cl-].[Mg+2].[Cl-].[S:18](=[O:20])=[O:19].[OH-].[NH4+:22].[C:23](O)(=O)[CH3:24]>[Cu](Cl)Cl>[Br:1][C:2]1[CH:8]=[CH:7][C:6]([S:18]([NH2:22])(=[O:20])=[O:19])=[C:23]([CH3:24])[CH:3]=1

参加物

9

反応物 7

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 14923Ammonium HydroxideHCID 82187Benzenamine, 3-bromo-4-methyl-HCID 5360315Magnesium ChlorideHCID 23668193Sodium Nitrite

生成物 1

HCID 206167674-Bromo-2-methylbenzene-1-sulfonamide

試薬・触媒・溶媒 1

HCID 24014Cupric Chloride触媒

実験手順

Prepared by the method of Example 69a) using 3-bromo-4-methylaniline (2.60 g, Example 78a)), sodium nitrite (1.05 g), concentrated hydrochloric acid (20 ml), anhydrous magnesium chloride (2.6 g), acetic acid saturated with sulfur dioxide (50 ml) and copper (II) chloride (0.37 g). The normal work-up and subsequent treatment with ammonium hydroxide (50 ml) followed by the same work-up afforded the subtitle compound as a solid (1.51 g).

後処理

  1. customPrepared by the method of Example 69a)

出典と根拠

ORDレコード
ord-6eed423eaf45419abf435b98bb927e2c
出典データセット
uspto-grants-2001_10
特許番号
US06300352B1

反応ノート

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