Sulfuric Acid → 5-bromo-2-fluorobenzamide

HRID 380047ノート

反応式

HRID 380047 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[C:7]#[N:8].S(=O)(=O)(O)[OH:12]>>[F:10][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:9][C:6]=1[C:7]([NH2:8])=[O:12]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 27249005-Bromo-2-fluorobenzonitrile

生成物 1

HCID 27789015-bromo-2-fluorobenzamide

実験手順

5-Bromo-2-fluorobenzonitrile (0.370 g) was heated at 110° C. for 1 hour in concentrated sulfuric acid (10 ml). After cooling, the reaction was diluted with ice-cold water and the slurry was extracted into ethyl acetate, dried over anhydrous magnesium sulfate, filtered and evaporated to afford the sub-title compound as a solid (0.328 g).

後処理

  1. temperatureAfter cooling
  2. additionthe reaction was diluted with ice-cold water
  3. extractionthe slurry was extracted into ethyl acetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-05e4d315ff034bdb8df2b36a7570b13d
出典データセット
uspto-grants-2001_10
特許番号
US06300352B1

反応ノート

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