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Potassium Carbonate → 1-[(4,5-Diphenyloxazol-2-yl)methylamino]-1,2,3,4-tetrahydro-5-methoxynaphthalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine | HCID 38899 | — |
| 反応物 | 2-Bromomethyl-4,5-diphenyl-oxazole | HCID 568599 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-[(4,5-Diphenyloxazol-2-yl)methylamino]-1,2,3,4-tetrahydro-5-methoxynaphthalene | HCID 18367394 | 76.5% |
反応手順
A solution of 1,2,3,4-tetrahydro-5-methoxy-1-naphthalenamine (0.34 g), (4,5-diphenyloxazol-2-yl)methyl bromide (0.50 g) and potassium carbonate (0.60 g) in DMF (7 ml) was stirred for 5 hours at room temperature. The mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine. The dried solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel to give 1-[(4,5-diphenyloxazol-2-yl)methylamino]-1,2,3,4-tetrahydro-5-methoxynaphthalene (0.50 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06300344B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-4e86e2e5d5f74d80b335f378c6f4041d |
| 出典メモ | uspto-grants-2001_10 |