Methyl Salicylate → N-Propylsalicylamide

反応式

[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[CH2:12]([NH2:15])[CH2:13][CH3:14]>>[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:15][CH2:12][CH2:13][CH3:14])=[O:6]

参加物

反応物 2

HCID 4133Methyl Salicylate

HCID 7852Propylamine

生成物 1

HCID 81966N-Propylsalicylamide収率 84%

反応条件

温度: 80 °C

実験手順

The crude methyl 2-hydroxybenzoate was dissolved in n-propylamine (400 mL). The reaction mixture in a sealed reactor was stirred at 80° C. overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by silica gel flash column chromatography to afford 120 g (84%) of 2-hydroxy-N-propylbenzamide. LCMS ESI (+) m/z 180 (M+1) detected.

後処理

concentrationThe reaction mixture was concentrated under reduced pressure
customto give the crude material that
customwas purified by silica gel flash column chromatography

出典と根拠

ORDレコード: ord-469bd8986c634922893dbc45d4e96c95
出典データセット: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08524702B2

反応ノート

読み込み中…

参加物