Methyl Salicylate → N-Propylsalicylamide

HRID 38015

反応式

HRID 38015 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[CH2:12]([NH2:15])[CH2:13][CH3:14]>>[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:15][CH2:12][CH2:13][CH3:14])=[O:6]

参加物

3

反応物 2

HCID 4133Methyl SalicylateHCID 7852Propylamine

生成物 1

HCID 81966N-Propylsalicylamide収率 84%

反応条件

温度
80 °C

実験手順

The crude methyl 2-hydroxybenzoate was dissolved in n-propylamine (400 mL). The reaction mixture in a sealed reactor was stirred at 80° C. overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by silica gel flash column chromatography to afford 120 g (84%) of 2-hydroxy-N-propylbenzamide. LCMS ESI (+) m/z 180 (M+1) detected.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto give the crude material that
  3. customwas purified by silica gel flash column chromatography

出典と根拠

ORDレコード
ord-469bd8986c634922893dbc45d4e96c95
出典データセット
uspto-grants-2013_09
特許番号
US08524702B2

関連ノート

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