化工社化工社 化学情報印刷レポート · 研究参考用
o-Bromo-nitrostyrene → 2-Bromophenethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | o-Bromo-nitrostyrene | HCID 187792 | — |
| 反応物 | Potassium bisulfate | HCID 516920 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Bromophenethylamine | HCID 2734091 | — |
反応手順
To the styrene of Step 1 (0.310 g, 1.3 mmol) in 5 mL of THF was added 1 M LiAlH4 solution in THF (5.2 mL, 5.2 mmol) at 0° C. The solution was stirred for 1 hour. A concentrated KHSO4 solution was added dropwise to destroy the excess of LiAlH4. The solution was filtered over celite and the filtrate concentrated in vacuo to give a yellow oil; 150 mg (58%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06300501B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-ab63b32f4e8645a9b7debf98a5dabaaf |
| 出典メモ | uspto-grants-2001_10 |