4-Methylcinnoline → 2-(1-aminopropan-2-yl)aniline
反応式
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[N:4][CH:3]=1>CO.[Ni]>[NH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=1[CH:2]([CH3:1])[CH2:3][NH2:4]参加物
4
実験手順
Reduction of 4-methyl-cinnoline (10 g, 69.5 mmol) in methanol (100 mL), using Raney nickel (3 g). The catalyst was removed and washed with methanol. The filtrate was treated with an excess of HCl in isopropanol; ether was then added and the solution cooled. The precipitate was filtered and dried; 9.4 g (60%).
後処理
- customThe catalyst was removed
- washwashed with methanol
- additionThe filtrate was treated with an excess of HCl in isopropanol
- additionether was then added
- temperaturethe solution cooled
- filtrationThe precipitate was filtered
- customdried
出典と根拠
- ORDレコード
- ord-f5ea5606d1254eb3a8970a90b37e595f
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06300501B1
反応ノート
読み込み中…