Water → 7-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

HRID 380239ノート

反応式

HRID 380239 の反応式
[OH2:1].[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8](Cl)=[O:9]>O1CCOCC1>[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8]([OH:1])=[O:9]

参加物

4

反応物 2

HCID 962WaterHCID 27576813-Chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride

生成物 1

HCID 183643997-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

40 ml of water are added to a solution of 70 mmol of the compound of Step A in 250 ml of dioxane. After 20 hours' reflux and then return to ambient temperature, a precipitate forms. After filtration and rinsing with water until neutral, the precipitate is dried over P2O5 under reduced pressure, allowing the expecting product to be isolated.

後処理

  1. temperatureAfter 20 hours' reflux
  2. customreturn to ambient temperature
  3. filtrationAfter filtration
  4. washrinsing with water until neutral, the precipitate
  5. dry with materialis dried over P2O5 under reduced pressure
  6. customto be isolated

出典と根拠

ORDレコード
ord-7f547cf8cb824ce4b1eb138bd2bd2e6d
出典データセット
uspto-grants-2001_10
特許番号
US06302837B1

反応ノート

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