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(1s,4r)-4-Propylcyclohexane-1-carboxylic acid → 4-Ethynyl-4'-propylbicyclohexyl-4-yl 4-propylcyclohexanecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1s,4r)-4-Propylcyclohexane-1-carboxylic acid | HCID 1490324 | — |
| 反応物 | 4-Ethynyl-4'-propylbicyclohexyl-4-ol | HCID 18364504 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Ethynyl-4'-propylbicyclohexyl-4-yl 4-propylcyclohexanecarboxylate | HCID 18364509 | — |
反応手順
4.00 g of 4-(dimethylamino)pyridine are added to a solution of 16.00 g of 4-ethynyl-4′-propylbicyclohexyl-4-ol and 11.51 g of 4-propylcyclohexanecarboxylic acid in 120 ml of dichloromethane. 9.66 g of N,N-dicyclohexylcarbodiimide in 30 ml of methylene chloride are subsequently added dropwise at RT, and the mixture is stirred overnight. Conventional work-up gives 4-ethynyl-4′-propylbicyclohexyl-4-yl 4-propylcyclohexane-carboxylate (C 59 N 120 I, Δε−1.57, Δn 0.04).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06303194B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-a96f2bb302f6403a9cceb95ee0e5273e |
| 出典メモ | uspto-grants-2001_10 |