化工社化工社 化学情報印刷レポート · 研究参考用
Lawesson's reagent → 3-Amino-2-thiophenecarbothioamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lawesson's reagent | HCID 87949 | — |
| 反応物 | 3-Aminothiophene-2-carboxamide | HCID 518993 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Amino-2-thiophenecarbothioamide | HCID 14321102 | 57.1% |
反応手順
A solution of 3-aminothiophene-2-carboxamide (4.5 g, 31 mmol) in tetrahydrofuran was treated with Lawesson's Reagent (7.7 g, 190 mmol) and the solution was stirred at room temperature for 18 h. The solvent was removed and the residue purified by chromatography on silica gel using dichloromethane as eluent. The product was obtained as a yellow powder (2.8 g, 56%), m.p. 98-99° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06303613B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-b8dbf243a8a842919d2cafadcf065e20 |
| 出典メモ | uspto-grants-2001_10 |