Bromine → 4-(4-Bromophenyl)piperidine

反応式

[Br:1]Br.[C:3]1([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>>[NH3:12].[Br:1][C:6]1[CH:7]=[CH:8][C:3]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[CH:4][CH:5]=1

参加物

反応物 2

HCID 24408Bromine

HCID 698734-Phenylpiperidine

生成物 2

HCID 222Ammonia

HCID 27571594-(4-Bromophenyl)piperidine収率 127%

実験手順

A solid mixture comprised of 2.65 g (16.4 mmol) of bromine adsorbed onto 5 g of Al2O3 was combined with a solid mixture of 1.05 g (6.56 mmol) of 4-phenylpiperidine adsorbed onto 5 g of Al2O3 and the combined mixture was stirred at rt for 2 h. The mixture was then put into a filter funnel and was eluted with CH2Cl2: EtOAc, 1:1 then CH2Cl2: MeOH:(2N NH3 in MeOH), 100:4:2 to give 1.0 g of the title compound.