Potassium Hydroxide → 1,3-Benzoxazole-7-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[C:13]2[O:12][CH:11]=[N:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].[OH-].[K+]>CO.O>[O:12]1[C:13]2[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=[CH:8][C:9]=2[N:10]=[CH:11]1参加物
5
実験手順
To a solution of 0.21 g (1.18 mmol) of methyl-7-benzoxazole carboxylate in 6 mL of CH3OH at 0° C. was added 2.9 mL of a 1N solution of KOH in water and the reaction mixture was stirred at rt for 1 h. The reaction mixture was partitioned between water and CH2Cl2. The aqueous fraction was made acidic with 1N HCl solution and extracted with CH2Cl2. The organic fraction was dried over Na2SO4, filtered and the filtrate was concentrated to give 0.17 g of the title compound as a yellow solid.
後処理
- customThe reaction mixture was partitioned between water and CH2Cl2
- extractionextracted with CH2Cl2
- dry with materialThe organic fraction was dried over Na2SO4
- filtrationfiltered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-b96fba2f4bc645568591289279a61574
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06303593B1
反応ノート
読み込み中…