Tetraethyltin → 7-Ethyl-5-nitro-1,3-benzothiazole
反応式
Br[C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.[CH2:14]([Sn](CC)(CC)CC)[CH3:15]>CCOC(C)=O>[CH2:14]([C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1)[CH3:15]参加物
4
実験手順
A solution of 7-bromo-5-nitrobenzothiazole (0.15 g, 0.58 mmol), tetraethyltin (0.18 mL, 0.87 mmol) and catalytic amount of Cl2Pd(PPh3)2 in a sealed tube was stirred for 12 h at 90° C. The reaction mixture was diluted with EtOAc and washed with brine several times. Organic solution was dried over Na2SO4 and concentrated in vacuo, yielding an oil which was subjected to column chromatography (EtOAc, neat) to provide 91 mg (0.44 mmol, 75%) of the desired product.
後処理
- washwashed with brine several times
- dry with materialOrganic solution was dried over Na2SO4
- concentrationconcentrated in vacuo
- customyielding an oil which
出典と根拠
- ORDレコード
- ord-f1220a4cbf964c148f62ecaec8b62f74
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06303643B1
反応ノート
読み込み中…