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Triethylamine → 3-[4-(4-Methylbenzyl)piperazin-1-yl]propanethiol dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | 1-(4-Methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153192 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[4-(4-Methylbenzyl)piperazin-1-yl]propanethiol dihydrochloride | HCID 13731120 | 72% |
反応手順
The procedure described in Example 1(b) was followed, using 7.7 g of thiourea, 23.0 g of 1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride, 6.5 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 6.0 g of sodium hydroxide in 40 ml of water. Work-up, as described above, gave 16.4 g (72% of theory) of 3-[4-(4-methylbenzyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 273°-277° C. (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722926 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-76581291372d4210a560be5a42ab7838 |
| 出典メモ | uspto-grants-1988_02 |