tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate → (S)-N-Boc-2-ethynylpyrrolidine

HRID 380874ノート

反応式

HRID 380874 の反応式
[C:1]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH:13]=O)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:15]C(C)([O-])C.[K+].C(OP(C=[N+]=[N-])(=O)OCC)C>CCOCC>[C:1]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]#[CH:15])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

参加物

5

反応物 3

HCID 2734674tert-butyl (2S)-2-formylpyrrolidine-1-carboxylateHCID 10943016Diazomethyl-phosphonic-acid-diethylesterHCID 23665647Potassium tert-butoxide

生成物 1

HCID 11030701(S)-N-Boc-2-ethynylpyrrolidine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

(S)-N-Boc-2-Ethynyl-pyrrolidine was prepared according to Method X above by the treatment of (S)-N-Boc-2-formyl-pyrrolidine (470 mg, 2.36 mmol) (Example 87A above) with potassium tert-butoxide (340 mg, 3.07 mmol) and diazomethyl-phosphonic-acid-diethylester (550 mg, 3.07 mmol) (also prepared according to Method X). The product was obtained after silica gel column chromatography with 10% Et2O in hexanes. (Yield 200 mg, 43%).

後処理

  1. customalso prepared

出典と根拠

ORDレコード
ord-80de765d0664493da5b5d1bcd9c381ed
出典データセット
uspto-grants-2001_10
特許番号
US06303793B1

反応ノート

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