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Dimethyl Sulfoxide → 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 4-Chlorobenzyl-2,5-dimethylpiperazine | HCID 22313576 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine | HCID 20153190 | 58% |
反応手順
22.0 g g of 1-bromo-3-chloropropane were added to a mixture of 33.0 g of 4-chlorobenzyl-2,5-dimethylpiperazine, 25.0 g of potassium hydroxide and 125 ml of dimethyl sulfoxide. After stirring the solution for 3 hours at room temperature, water was added, the product was extracted with ether, and the extract was dried (magnesium sulfate) and concentrated to give 25.8 g (58% of theory) of 1-(4-chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine as an oil, suitable for use in the next reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722926 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-73dfc2a4ed354bdeacc95510bbfc783d |
| 出典メモ | uspto-grants-1988_02 |