Water → 2-(2-Fluoro-4-iodophenyl)acetic acid

HRID 381018ノート

反応式

HRID 381018 の反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]#N.[OH2:12].[OH-:13].[K+]>C(O)C>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:13])=[O:12]

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 222405322-(2-Fluoro-4-iodophenyl)acetonitrile2 回

生成物 1

HCID 222403932-(2-Fluoro-4-iodophenyl)acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-fluoro4-iodo-phenyl acetonitrile (Intermediate 2, 2.05 g, 7.83 mmol) in ethanol (50 mL and water (15 mL) was treated with potassium hydroxide (3.4 g, 60.7 mmol) and refluxed for 4 h. The volatiles were distilled off in vacuo and the residue was diluted with water and poured into cold, dilute hydrochloric acid and the precipitated solid was filtered. The solid was dissolved in diethyl ether, and the organic solution was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound a pale yellow solid (1.75 g, 79%/o).

後処理

  1. temperaturerefluxed for 4 h
  2. distillationThe volatiles were distilled off in vacuo
  3. additionthe residue was diluted with water
  4. additionpoured into cold, dilute hydrochloric acid
  5. filtrationthe precipitated solid was filtered
  6. dissolutionThe solid was dissolved in diethyl ether
  7. dry with materialthe organic solution was dried over anhydrous magnesium sulfate
  8. filtrationfiltered
  9. customevaporated in vacuo

出典と根拠

ORDレコード
ord-8dfe84233aed49cfbdb7999a087eb4ac
出典データセット
uspto-grants-2001_10
特許番号
US06303785B1

反応ノート

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