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Ethanol → 3-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | 1-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine | HCID 20153190 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride | HCID 20153172 | 249.9% |
反応手順
The procedure described in Example 1(b) was followed, using 12.7 g of thiourea and 26.0 g of 1-(4-chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine in 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 26.5 g (83% of theory) of 3-[4-(4-chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 168°-171° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722926 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-ac25165bc3e44b80977c05d9becefbc7 |
| 出典メモ | uspto-grants-1988_02 |