Potassium Carbonate → [1-(4-Ethynylphenyl)-cyclopropyl]-propylamine
反応式
[CH2:1]([NH:4][C:5]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[C:15][Si](C)(C)C)=[CH:10][CH:9]=2)[CH2:7][CH2:6]1)[CH2:2][CH3:3].C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2([NH:4][CH2:1][CH2:2][CH3:3])[CH2:6][CH2:7]2)=[CH:9][CH:10]=1)#[CH:15]参加物
4
実験手順
Using General Procedure E; propyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine (Intermediate 119, 80.0 mg, 0.30 mmols) in methanol (8 mL) was treated with potassium carbonate (80.0 mg, 0.59 mmol) and stirred overnight at ambient temperature. The crude alkyne (58 mg, 100%) was used directly in the next reaction.
出典と根拠
- ORDレコード
- ord-333084c7a31842139d55999e06579145
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06303785B1
反応ノート
読み込み中…