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1-Bromo-3-chloropropane → 1-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1-(1-Phenylethyl)piperazine | HCID 2737134 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 1-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153170 | 409.8% |
反応手順
The procedure described in Example 17(a) was followed, using 16.5 g of 1-(1-phenylethyl)piperazine, 8.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 9.5 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 28.0 g (96% of theory) of 1-(1-phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722926 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-93cf949e00b544a7b8fbd151bc44a719 |
| 出典メモ | uspto-grants-1988_02 |