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N-Methylaniline → (Methyl-phenyl-amino)-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylaniline | HCID 7515 | — |
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (Methyl-phenyl-amino)-acetic acid ethyl ester | HCID 265936 | — |
反応手順
A solution of 16.7 g (100 mmol) of ethyl bromoacetate, 10.7 g (100 mmol) of N-methylaniline, and 12.9 g (100 mmol) of N,N-diisopropylethylamine in 100 mL of acetonitrile was allowed to stand for 24hr. and then diluted with 200 ml of ether. The amine salt was filtered and the filtrate concentrated, dissolved in 150 ml of CH2Cl2, washed with water, filtered through a plug of sodium sulfate/silica and distilled: 15.5 g (80%), b.p. 132°/12 mm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06306570B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-e2aa5949263c41908cefd6a9f8769616 |
| 出典メモ | uspto-grants-2001_10 |