関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Diethyl Adipate | HCID 8844 | — |
| 反応物 | 1-(Bromomethyl)-2-phenylbenzene | HCID 263365 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(2-Phenyl-benzyl) adipic acid diethylester | HCID 15913968 | 92% |
反応手順
Into a 3 neck flask, equipped with water cooler, were added 43.8 mL (0.22 mol) of diethyladipate and 220 mL THF. 16.3 g (0.24 mol, 1.1 equivalents) of NaOEt were added in small portions, at 20° C., and the reaction mixture was stirred at 60° C. for 16 hours. After cooling to 20° C., 48.6 g (0.20 mol) of 2-phenyl-benzyl bromide was added dropwise. The reaction mixture was stirred at 60° C., for 16 hours, to give 2-(2-phenyl-benzyl) adipic acid diethylester as a viscous oil, in a yield of 92%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06306791B2 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-332db244a6984dc390f1abd5a2fc578b |
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| 出典メモ | uspto-grants-2001_10 |
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