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Triethylamine → 3-[4-(1-Phenylethyl)piperazin-1-yl]propanethiol dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | 1-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153170 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[4-(1-Phenylethyl)piperazin-1-yl]propanethiol dihydrochloride | HCID 13731122 | 51% |
反応手順
The procedure described in Example 1(b) was followed, using 9.8 g of thiourea, 29.0 g of 1-(1-phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride, 8.3 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 6.0 g of sodium hydroxide in 40 ml of water. Work-up, as above, gave 14.5 g (51% of theory) of 3-[4-(1-phenylethyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 252°-255° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722926 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-d017d716638549a595ea280009b45216 |
| 出典メモ | uspto-grants-1988_02 |