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Oxalyl chloride → 5-Chlorothiophene-2-carbonyl Chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-Chlorothiophene-2-carbonyl Chloride | HCID 589223 | — |
反応手順
To a chilled solution of 5-chlorothiophene-2-carboxylic acid (0.16 g, 1.0 mmol) in EtOAc (3 mL) and DMF (1 drop) was added neat oxalyl chloride (92 μL, 1.05 mmol). The reaction mixture was stirred cold for 2 hr and concentrated in vacuo to give crude 5-chlorothiophene-2-carbonyl chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524721B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-f3ab523db84d4747a39bf21f2f7e9033 |
| 出典メモ | uspto-grants-2013_09 |