関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sulfanilamide | HCID 5333 | — |
| 反応物 | Phthaloyl chloride | HCID 6955 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 4-(1,3-Dioxo-1,3-dihydro-isoindol-2-YL)-benzenesulfonamide | HCID 3586494 | 90.1% |
反応手順
A solution of 1.0 g (5.8 mmol) of p-aminophenylsulfonamide in 3.6 mL of pyridine was added 878 μL (6.1 mmol) of phthalic dichloride. After heating to 60° C. for 18 h, the solution was poured into 1N HCl, cooled to 0° C., the precipitate was collected by filtration, and dried under vacuum to give 1.58 g (90%) of the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524721B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-51cd8d87d0e24a22a7382f7575191e3a |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
