関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| 反応物 | tert-Butyl 4-(acetylthio)piperidine-1-carboxylate | HCID 22494773 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-(Acetylthio)piperidine hydrochloride | HCID 18363290 | 94% |
反応手順
In 45 ml of ethyl acetate were dissolved 1.25 g (4.82 mmol) of 4-(acetylthio)-1-(tert-butoxycarbonyl)piperdine as described in Reference example 11, and 12.0 ml (48.2 mmol) of a 4N hydrogen chloride-ethyl acetate solution were added to the solution, followed by stirring of the resulting mixture at 50° C. for 4 hours. After cooling, the precipitated solid was collected by filtration and washed with hexane to obtain 885 mg (yield: 94%) of the desired compound as a slightly yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06306880B1 |
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| 出典データセット | uspto-grants-2001_10 |
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| ORD ID | ord-6c1c4656a7cd48f4adc4a61e0e02642c |
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| 出典メモ | uspto-grants-2001_10 |
|---|
