化工社化工社 化学情報印刷レポート · 研究参考用
1,8-Diazabicyclo(5.4.0)undec-7-ene → [4-(2,4-Dioxo(1,3-dihydroquinazolin-3-yl))phenyl]-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | Methyl 2-isocyanatobenzoate | HCID 519494 | — |
| 反応物 | (4-Aminophenyl)-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide | HCID 131724995 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | [4-(2,4-Dioxo(1,3-dihydroquinazolin-3-yl))phenyl]-n-[(5-chloro(2-thienyl))sulfonyl]carboxamide | HCID 20800263 | 34% |
反応手順
A 44 mg portion (0.14) of (4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide was combined with 25 mg (0.14 mmol) of methyl 2-isocyanatobenzoate in 500 uL of THF followed by the addition of 1 equivalent of TEA (24 μL) and 1 equivalent of DBU. After 18 h, the mixture was purified by RP-HPLC, to give 21 mg (34%) of the desired compound. ES-MS (M+H)+=462 (Cl).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524721B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-75f7eae99314419cb9893602e8a3a03e |
| 出典メモ | uspto-grants-2013_09 |