Pentafluoropyridine → 2,3,5,6-Tetrafluoro-4-methoxypyridine
反応式
[F:1][C:2]1[N:7]=[C:6]([F:8])[C:5]([F:9])=[C:4](F)[C:3]=1[F:11].[CH3:12][O-:13].[Na+]>>[CH3:12][O:13][C:4]1[C:3]([F:11])=[C:2]([F:1])[N:7]=[C:6]([F:8])[C:5]=1[F:9]参加物
3
実験手順
To pentafluoropyridine (1.0 g, 5.9 mmol) in petroleum ether (60 mL) at 0° C. was added sodium methoxide (0.32 mg, 5.9 mmol). After stirring for 12 hours at ambient temperature, the reaction was washed with water, dried (MgSO4), and the solvent was removed in vacuo to give 4-methoxy-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 4.3 ppm.
後処理
- washthe reaction was washed with water
- dry with materialdried (MgSO4)
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-615eff473bbf4d638f832f9423b112e5
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06306884B1
反応ノート
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