Pentafluoropyridine → 2,3,5,6-Tetrafluoro-4-methoxypyridine

HRID 381450

反応式

HRID 381450 の反応式
[F:1][C:2]1[N:7]=[C:6]([F:8])[C:5]([F:9])=[C:4](F)[C:3]=1[F:11].[CH3:12][O-:13].[Na+]>>[CH3:12][O:13][C:4]1[C:3]([F:11])=[C:2]([F:1])[N:7]=[C:6]([F:8])[C:5]=1[F:9]

参加物

3

反応物 2

HCID 69690PentafluoropyridineHCID 10942334Sodium Methoxide

生成物 1

HCID 139996172,3,5,6-Tetrafluoro-4-methoxypyridine

実験手順

To pentafluoropyridine (1.0 g, 5.9 mmol) in petroleum ether (60 mL) at 0° C. was added sodium methoxide (0.32 mg, 5.9 mmol). After stirring for 12 hours at ambient temperature, the reaction was washed with water, dried (MgSO4), and the solvent was removed in vacuo to give 4-methoxy-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 4.3 ppm.

後処理

  1. washthe reaction was washed with water
  2. dry with materialdried (MgSO4)
  3. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-615eff473bbf4d638f832f9423b112e5
出典データセット
uspto-grants-2001_10
特許番号
US06306884B1

関連ノート

読み込み中…