関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Aminocinnamic acid | HCID 1549514 | — |
| 反応物 | Potassio isocyanate | HCID 11051572 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (E)-3-(4-Ureidophenyl)acrylic acid | HCID 18363098 | 80% |
反応手順
A stirred solution of (E)-3-(4-aminophenyl)acrylic acid (1.0 g, 5.0 mmol) and potassium isocyanate (2.0 g, 5 equiv.) in a mixture of water and acetic acid (50 mL) was heated at 100° C. for 12 hours. After cooling, a white solid precipitated out. Filtration, washing of the filter cake with a mixture of water and MeOH, and drying it in vacuo gave the title compound (0.82 g, 80%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06306870B1 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-e42b2324aa1745b0b1fc7aada8631e35 |
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| 出典メモ | uspto-grants-2001_10 |
|---|
