1H-Pyrazol-3-amine, 5-methyl- → 2-Chloro-n-(5-methyl-1h-pyrazol-3-yl)quinazolin-4-amine
反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1>C(O)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:19][C:16]2[CH:15]=[C:14]([CH3:13])[NH:18][N:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
4
実験手順
To a solution of 2,4-dichloro-quinazoline (3.3 g, 16.6 mmol) in anhydrous ethanol (150 mL) is added 5-methyl-1H-pyrazol-3-yl amine (3.2 g, 32.9 mmol). The mixture is stirred at room temperature for 4 h, and the resulting precipitate is collected by filtration, washed with ethanol, and dried under vacuum to afford (2-chloro-quinazolin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.
後処理
- filtrationthe resulting precipitate is collected by filtration
- washwashed with ethanol
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-a54e6a451ecb4ab2aa1108d865204bf9
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524720B2
反応ノート
読み込み中…