1H-Pyrazol-3-amine, 5-methyl- → 2-Chloro-n-(5-methyl-1h-pyrazol-3-yl)quinazolin-4-amine

HRID 38170

反応式

HRID 38170 の反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1>C(O)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:19][C:16]2[CH:15]=[C:14]([CH3:13])[NH:18][N:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

4

反応物 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 2528862,4-Dichloroquinazoline

生成物 1

HCID 219391632-Chloro-n-(5-methyl-1h-pyrazol-3-yl)quinazolin-4-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2,4-dichloro-quinazoline (3.3 g, 16.6 mmol) in anhydrous ethanol (150 mL) is added 5-methyl-1H-pyrazol-3-yl amine (3.2 g, 32.9 mmol). The mixture is stirred at room temperature for 4 h, and the resulting precipitate is collected by filtration, washed with ethanol, and dried under vacuum to afford (2-chloro-quinazolin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

後処理

  1. filtrationthe resulting precipitate is collected by filtration
  2. washwashed with ethanol
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-a54e6a451ecb4ab2aa1108d865204bf9
出典データセット
uspto-grants-2013_09
特許番号
US08524720B2

関連ノート

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