化工社化工社 化学情報印刷レポート · 研究参考用
Ethylene Glycol → Simvastatin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | 1,3-Propanediol | HCID 10442 | — |
| 反応物 | Neopentyl glycol | HCID 31344 | — |
| 反応物 | HCID 178445512 | HCID 178445512 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Simvastatin | HCID 54454 | — |
反応手順
Simvastatin boronate (III) is heated in the presence of a suitable diol solvent selected from ethylene glycol, 1,3-propanediol, or neopentyl glycol, under thermal conditions. The product is isolated by concentration of the reaction mixture, dilution with water, and extraction with an organic solvent. The organic solvent is concentrated to a minimum volume and simvastatin is isolated by the addition of a cosolvent and filtration.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06307066B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-668282ea8a434ec39afca7f89dc75d3b |
| 出典メモ | uspto-grants-2001_10 |