4-Toluenesulfonyl chloride → (R)-1-Benzyl-3-pyrrolidinol tosylate

HRID 381735

反応式

HRID 381735 の反応式
[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1([CH3:24])[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>O>[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[S:20]([C:17]1[CH:18]=[CH:19][C:14]([CH3:24])=[CH:15][CH:16]=1)([O-:13])(=[O:22])=[O:21]

参加物

4

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 643472(R)-(+)-1-Benzyl-3-pyrrolidinol

生成物 1

HCID 86583595(R)-1-Benzyl-3-pyrrolidinol tosylate収率 175.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred solution of (R)1-benzyl-3-pyrrolidinol (1.77 g, 10 mmol) pyridine(30 ml) was added p-toluenesulfonyl chloride (9.53 g, 50 mmol) by portions at 0° C. After 90 h stirring at room temperature, water was added to the reaction mixture and the mixture was extracted with ether (150 ml). The extract was washed with water brine, dried (Na2SO4), and concentrated to give 3.06 g (92%) of brown oil.

後処理

  1. extractionthe mixture was extracted with ether (150 ml)
  2. washThe extract was washed with water brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-83b8f201dfb748bdafa93b0432845b9a
出典データセット
uspto-grants-2001_10
特許番号
US06307061B2

関連ノート

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