関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | Ethyl 4,4,4-trifluoro-3-hydroxybutanoate | HCID 136210 | 96.4% |
反応手順
Ethyl 4,4,4-trifluoroacetoacetate (350 g), under a blanket of nitrogen gas, was heated to 40° C. and treated with platinum (0.7 g of 5% Pt/C, 0.01% load) and triethylamine (1.5 g, 0.4% load). Hydrogen was charged to a pressure of 5 bars and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 341 g (96% yield) of ethyl 4,4,4-trifluoro-3-hydroxybutyrate was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06307094B1 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-e7db54e81976455db6cd5c05ccfe7b32 |
|---|
| 出典メモ | uspto-grants-2001_10 |
|---|
