Dihydrocoumarin → N,N-diethyl-3-(2-hydroxyphenyl)propanamide

HRID 381811

反応式

HRID 381811 の反応式
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[CH:6]1[CH:7]=[CH:8][C:9]2[O:16][C:14](=[O:15])[CH2:13][CH2:12][C:10]=2[CH:11]=1>>[CH2:1]([N:3]([CH2:4][CH3:5])[C:14](=[O:15])[CH2:13][CH2:12][C:10]1[CH:11]=[CH:6][CH:7]=[CH:8][C:9]=1[OH:16])[CH3:2]

参加物

3

反応物 2

HCID 660DihydrocoumarinHCID 8021Diethylamine

生成物 1

HCID 45803915N,N-diethyl-3-(2-hydroxyphenyl)propanamide収率 113.8%

実験手順

Diethylamine (98.5 g) and dihydrocoumarin (20.0 g) were refluxed for 4 hours. Excess diethylamine was removed in vacuo to leave 34.0 g of N,N-diethyl-3-(2-hydroxyphenyl) propionamide. 1H NMR (CDCl3): 7.26-7.03 (m, 2H), 6.91 (dd, 1H), 6.81 (td, 1H), 3.37 (quartet, 2H), 3.26 (quartet, 2H), 2.95 (m, 2H), 2.71 (m, 2H), 1.10 (quartet, 6H).

後処理

  1. customExcess diethylamine was removed in vacuo

出典と根拠

ORDレコード
ord-1b577bb95e5346a6a27b7b3fc3b3c2db
出典データセット
uspto-grants-2001_10
特許番号
US06307107B1

関連ノート

読み込み中…