化工社化工社 化学情報印刷レポート · 研究参考用
Bromobenzene → Methyl 4-(4-bromophenyl)-4-oxobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromobenzene | HCID 7961 | — |
| 反応物 | Butanoic acid, 4-chloro-4-oxo-, methyl ester | HCID 73888 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 4-(4-bromophenyl)-4-oxobutanoate | HCID 838865 | — |
反応手順
In a manner similar to Example 2, Step (a), bromobenzene (10.0 mL, 0.0950 mol) was allowed to react with 3-carbomethoxypropionyl chloride (12.9 mL, 0.105 mol) in the presence of aluminum chloride (26.9 g, 0.0202 mol) in dichloromethane to give, after chromatography on silica gel (435 g, 230-400 mesh), eluting with hexanes-acetone (9:1, 10×400 mL; 8:1, 7×400 mL), 21.2 g of 4-(4-bromo-phenyl)-4-oxo-butyric acid, methyl ester as an off-white solid; mp 49-51° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06307089B2 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-617a969c2e0f473d93ee8180621ea705 |
| 出典メモ | uspto-grants-2001_10 |