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Sodium Carbonate → 4-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | 4-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid | HCID 23005240 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid | HCID 86583517 | 60.9% |
反応手順
In a manner similar to Example 4, Step (c), 4-oxo-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid (1.20 g, 0.00372 mol) was allowed to react with hydroxylamine hydrochloride (0.3115 g, 0.00448 mol) in the presence of sodium carbonate (0.4768 g, 0.00450 mol) in absolute ethanol (20 mL) to give 0.764 g of 4-hydroxyimino-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid as a white solid; mp 134-136° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06307089B2 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-5a91edce8afc48488a6e61b0c25d134b |
| 出典メモ | uspto-grants-2001_10 |